JAK2 FISH Probe

The JAK2 FISH probe is designed to hybridize to the JAK2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping

Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU	Test Kits	Buffer
JAK2-20-OR (Standard Design)	20 (40 μL)	200 μL
JAK2-20-RE	20 (40 μL)	200 μL
JAK2-20-GO	20 (40 μL)	200 μL
JAK2-20-GR	20 (40 μL)	200 μL
JAK2-20-AQ	20 (40 μL)	200 μL
JAK2-20-DIG	20 (40 μL)	200 μL
JAK2-20-BIO	20 (40 μL)	200 μL

Gene Summary

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: JAK2

Gene Name: Janus Kinase 2

Chromosome: CHR9: 4985244-5128183

Locus: 9p24.1

FISH Probe Protocols

Protocol, Procedure, or Form Name	Last Modified	Download

JAK2 double minutes with resultant simultaneous amplification of JAK2 and CD274 in a therapy-related myelodysplastic syndrome evolving into an acute myeloid leukaemia

Amplification with double minutes (DM) of the JAK2 gene could potentially accelerate the progression of leukemia. FISH analysis was used in conjunction with SNP microarray to observe the effects of the amplification. FISH was performed using our JAK2 probe, showing multiple copies of JAK2 residing on the DMs. It was concluded that amplification of JAK2 could indeed contribute to progression of the disease.

First Case of Double T-Cell Receptor Alpha/Delta Rearrangements of t(11;14) and inv(14) and Subsequent JAK2 Rearrangement in a Patient with T-Cell Acute Lymphoblastic Leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is characterized by translocations of oncogenic transcription factor genes and T-cell receptor loci. This study reported the first case of T-ALL with TCR alpha/delta (TRA/D) locus rearrangements associated with t(11;14)(p13;q11.2), inv(14)(q11.2q32), and clonal evolution of JAK2 rearrangement. Our JAK2 break-apart probe was used to detect a novel JAK2 translocation, t(8;9)(p22;p24), in the subject under study. As the patient tested negative for JAK2 rearrangements at diagnosis, the translocation must have developed during disease progression.

The diagnostic challenges and clinical course of a myeloid/lymphoid neoplasm with eosinophilia and ZBTB20-JAK2 gene fusion presenting as B-lymphoblastic leukemia

JAK2 rearrangements are hallmarks of both Ph-Like B-cell ALL and myeloid/lymphoid neoplasms with eosinophilia and gene rearrangements (MLN-EGR). This study used our JAK2 break-apart probe to discover a new JAK2 fusion - ZBTB20/JAK2 - in a patient with B-ALL with eosinophilia. The team found that her disease originated with a JAK2-rearranged myeloid neoplasm that developed into B-ALL.

Product Details

Product: JAK2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: JAK2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping

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